
Another group of lipids is based off of isoprenoids, which are the building blocks of sterols (such as cholesterol). Glycerophospholipids and sphingolipids are essential constituents of cellular plasma membranes. Glycerolipids (triacylglycerols) are important for energy storage and thermal insulation. In addition, combining fatty acids with different bases, including glycerol, phosphate, and shingosine, results in different lipids with varied functions within the human body. Eicosanoids are a family of cell-signaling molecules with important physiologic properties derived from the fatty acid, arachadonic acid. Fatty acids are integral building blocks of lipids, and can be classified as unsaturated or saturated based on the presence/absence of carbon-carbon double bonds within their nonpolar chains. Lipids are a diverse group of hydrophobic organic molecules, which include fats, oils, sterols, and waxes. Degradation of nucleotides result in xanthine then uric acid production in purines, while pyrimidines produce the amino acids, β-alanine, and β-aminobutyrate. For thymine, a part of deoxyribonucleotides, ribonucleoside reductase is required to reduce the ribose moiety. Synthesis of pyrimidine nucleotides also follows different reactions, producing uridine monophosphate (UMP), which is converted to uridine triphosphate (UTP) and cytidine triphosphate (CTP). Purine synthesis is regulated in the 1st 2 steps. The de novo pathway generates inosine monophosphate (IMP), which is the precursor of adenosine monophosphate (AMP) and guanosine monophosphate (GMP).
Dr najeeb lectures too long series#
Purine nucleotide synthesis follows a series of reactions using carbon donors, amino acids (e.g., glutamine, aspartate), and bicarbonate. Purines include adenine and guanine, while pyrimidines include thymine (in DNA), uracil (in RNA), and cytosine. When you login to your account and play a video you’ll see fast video playback option in the video player.Purines and pyrimidines are heterocyclic aromatic compounds, which, along with sugar and phosphate groups, form the important components of nucleotides. You are not going to learn everthing again so do it right the first time.ĭon’t forget, Last knowledge results from clear concepts.
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These concepts that you master today will be deciding tomorrow how good of a medical professional you are going to be 10 years from now. What really differentiates a successful medical professional from an average medical professional is the difference in clarity of their concepts. Why do you need to Master Important Medical Concepts?Īs a Medical Professional you are probably going to practice all your life. Watch videos at 1.5x speed to learn more in less time. You can watch our videos at 1.5x speed to learn more in less time. We believe you cannot review what you never knew. This is precisely why our videos are long. You are an active part of the learning process.We are there to help you visualize complex medical concepts with hand drawn illustrations so you can Master Medical Sciences.

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